Micro-Mechanical Model of Muscle Contraction
نویسندگان
چکیده
منابع مشابه
Micro-mechanical model of muscle contraction
At the length scale of the fiber, the response of a muscle to rapid short increments in length, which is related to the power stroke (PS), is usually described using the model proposed by AF Huxley and RM Simmons in the 1971 [1], while the slower recovery of the initial tension and the force velocity behavior, which are related to the attachment-detachment process (AD), are usually described us...
متن کاملChemo-mechanical model for skeletal muscle contraction
Generation of force in skeletal muscle tissue depends on both chemical and mechanical phenomena. In this work, considering the kinetics of cross bridges, a one dimensional model has been proposed for predicting the isometric force according to the intracellular calcium ion distribution. Introduction The different ways of skeletal muscle activation lead to the formation of cross bridges (XB) acc...
متن کاملMuscle contraction: A mechanical perspective.
In this paper we present a purely mechanical analog of the conventional chemo-mechanical modeling of muscle contraction. We abandon the description of kinetics of the power stroke in terms of jump processes and instead resolve the continuous stochastic evolution on an appropriate energy landscape. In general physical terms, we replace hard spin chemical variables by soft spin variables represen...
متن کاملMolecular model of muscle contraction.
A quantitative stochastic model of the mechanochemical cycle of myosin, the protein that drives muscle contraction, is proposed. It is based on three premises: (i) the myosin head incorporates a lever arm, whose equilibrium position adjusts as each of the products of ATP hydrolysis dissociates from the nucleotide pocket; (ii) the chemical reaction rates are modified according to the work done i...
متن کاملA multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements
The presented chemo-electro-mechanical skeletal muscle model relies on a continuum-mechanical formulation describing the muscle's deformation and force generation on the macroscopic muscle level. Unlike other three-dimensional models, the description of the activation-induced behavior of the mechanical model is entirely based on chemo-electro-mechanical principles on the microscopic sarcomere l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.793